Question 1

Match each receptor listed in questions with the lettered ligand (A-E)that binds to the receptor.(Answers may be used more than once. )
P-selectin

A)B7-1,B7-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X

Sialylated Lewis X

Accepted Answer

VLA-4,an integrin expressed on T cells,binds to VCAM-1,an Ig superfamily member expressed on activated endothelium.VLA-4-VCAM-1 interactions promote T cell recruitment into inflammatory sites.

Question 2

Match each receptor listed in questions with the lettered ligand (A-E)that binds to the receptor.(Answers may be used more than once. )
P-selectin

A)B7-1,B7-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X

Sialylated Lewis X

Accepted Answer

Sialylated Lewis X is a carbohydrate structure on glycoprotein ligands of selectins expressed by endothelial cells (E-selectin and P-selectin)or leukocytes (L-selectin).Selectin binding to sialylated Lewis X structures mediates leukocyte rolling interactions with activated endothelium.

Question 3

Match each receptor listed in questions with the lettered ligand (A-E)that binds to the receptor.(Answers may be used more than once. )
P-selectin

A)B7-1,B7-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X

Sialylated Lewis X

Accepted Answer

LFA-3 on antigen-presenting cells binds to CD2 on T cells,and this interaction provides both adhesive and signaling functions that promote T cell activation.

Question 4

Match each receptor listed in questions with the lettered ligand (A-E)that binds to the receptor.(Answers may be used more than once. )
P-selectin

A)B7-1,B7-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X

Sialylated Lewis X

Accepted Answer

CTLA-4 on T cells binds to B7-1 and B7-2 on antigen-presenting cells,which prevents the B7 molecules from binding to CD28 and costimulating the T cells.

Question 5

For each component of a T cell receptor complex listed in questions match the lettered item (A-D)shown in the figure.&#10;  &#10;&#10;-CD3 protein&#10;

Accepted Answer

The answer of For each component of a T cell...

Question 6

Match each receptor listed in questions with the lettered ligand (A-E)that binds to the receptor.(Answers may be used more than once. )
P-selectin

A)B7-1,B7-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X

Sialylated Lewis X

Accepted Answer

CD4 on T cells binds to a nonpolymorphic region of class II MHC during T cell recognition of antigen.This molecular interaction promotes signaling events required for T cell activation.

Question 7

For each component of a T cell receptor complex listed in questions match the lettered item (A-D)shown in the figure.&#10;  &#10;&#10;-Antigen-binding region&#10;

Accepted Answer

The answer of For each component of a T cell...

Question 8

Match each receptor listed in questions with the lettered ligand (A-E)that binds to the receptor.(Answers may be used more than once. )
P-selectin

A)B7-1,B7-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X

Sialylated Lewis X

Accepted Answer

Sialylated Lewis X is a carbohydrate structure on glycoprotein ligands of selectins expressed by endothelial cells (E-selectin and P-selectin)or leukocytes (L-selectin).Selectin binding to sialylated Lewis X structures mediates leukocyte rolling interactions with activated endothelium.

Question 9

For each component of a T cell receptor complex listed in questions match the lettered item (A-D)shown in the figure.&#10;  &#10;&#10;-Immunoreceptor tyrosine-based activation motif (ITAM)&#10;

Accepted Answer

The answer of For each component of a T cell...

Question 10

For each component of a T cell receptor complex listed in questions match the lettered item (A-D)shown in the figure.&#10;  &#10;&#10;-z protein&#10;

Accepted Answer

The answer of For each component of a T cell...

Question 11

For each component of a T cell receptor listed in questions ,match the lettered region (A-C)shown in the figure.&#10;  &#10;&#10;-Constant Ig domain&#10;

Accepted Answer

The answer of For each component of a T cell...

Question 12

Match each receptor listed in questions with the lettered ligand (A-E)that binds to the receptor.(Answers may be used more than once. )
P-selectin

A)B7-1,B7-2
B)Class II MHC
C)LFA-3
D)VCAM-1
E)Sialylated Lewis X

Sialylated Lewis X

Accepted Answer

The answer of Match each receptor listed in questions with...

Question 13

For each component of a T cell receptor listed in questions ,match the lettered region (A-C)shown in the figure.&#10;  &#10;&#10;-Variable Ig domain&#10;

Accepted Answer

The answer of For each component of a T cell...

Question 14

For each component of a T cell receptor listed in questions ,match the lettered region (A-C)shown in the figure.&#10;  &#10;&#10;-Complementarity-determining regions&#10;

Accepted Answer

The answer of For each component of a T cell...

Deck 15: Antigen-Receptors