Deck 5: MHC

Question 1

For each region of a class I MHC molecule listed in questions,match the lettered label (A-D)from the diagram shown below.


-CD8-binding site

Answer 1

A
Class I MHC molecules bind to CD8 on T cells via the $\alpha$ 3 Ig domain of the $\alpha$ heavy chain.This is a region of the protein that is the same among different alleles,i.e.It is a nonpolymorphic part of the protein.

Question 2

For each region of a class I MHC molecule listed in questions,match the lettered label (A-D)from the diagram shown below.


-b2-Microglobulin

Answer 2

D
$\beta$ 2-microglobulin is a separate nonpolymorphic polypeptide containing a single Ig domain,which is noncovalently associated with the extracellular region of the $\alpha$ heavy chain of class I MHC molecules.

Question 3

Match each of the definitions in questions with the MHC nomenclature (A-F).
Inbred mouse strain MHC haplotype

A)HLA-A1,-B7,-C4,-DP5,-DQ10,-DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd

Answer 3

H-2KdI-AdI-EdDdLd

Question 4

For each region of a class I MHC molecule listed in questions,match the lettered label (A-D)from the diagram shown below.

Polymorphic region

Question 5

Match each of the definitions in questions with the MHC nomenclature (A-F).
Human MHC haplotype

A)HLA-A1,-B7,-C4,-DP5,-DQ10,-DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd

Question 6

For each region of a class I MHC molecule listed in questions,match the lettered label (A-D)from the diagram shown below.


-Peptide-binding groove

Question 7

Match each of the definitions in questions with the MHC nomenclature (A-F).
Mouse major histocompatibility complex

A)HLA-A1,-B7,-C4,-DP5,-DQ10,-DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd

Question 8

Match each of the definitions in questions with the MHC nomenclature (A-F).
Human class I MHC allele

A)HLA-A1,-B7,-C4,-DP5,-DQ10,-DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd

Question 9

Match each of the definitions in questions with the MHC nomenclature (A-F).
Mouse class II MHC allele

A)HLA-A1,-B7,-C4,-DP5,-DQ10,-DR8
B)H-2
C)HLA-DQ7
D)I-Ad
E)HLA-B5
F)H-2KdI-AdI-EdDdLd