Deck 12: Cytokines

Question 1

Which of the following is a major effect of interleukin-6 (IL-6)

A)B cell Ig class switching
B)Acute phase protein expression
C)Macrophage activation
D)T cell proliferation
E)Th2 differentiation

Answer 1

Acute phase protein expression

Question 2

Which of the following groups of cytokine receptors signaling though JAK-STAT pathways?

A)Receptors for TNF,Lymphotoxin,BAFF
B)Receptors for IL-8,CXCL13,CCL11
C)Receptors for IL-17
D)Receptors of IL-2,IL-4,and interferon-g

Answer 2

Receptors of IL-2,IL-4,and interferon-g

Question 3

For each of the following descriptions of a chemokine or chemokine receptor,select the chemokine or chemokine receptor (A-G)that most closely matches it.
Important for attracting B cells and Tfh cells into B cell follicles

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CXCL13

Answer 3

CXCL13

Question 4

The tumor necrosis factor (TNF)family of proteins includes several soluble and membrane proteins that share structural homologies.All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions ,select the term listed in options A-E that best matches it.
Expressed as a membrane molecule on the surface of activated T cells,it binds to a receptor found on many cell types,including T cells,and induces apoptosis.

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin/TNF-b

Question 5

For each of the descriptions of a biologic function in questions ,select the T cell-derived cytokine (A-E)that matches it.
Stimulates growth and activation of eosinophils

A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)IL-17

Question 6

The tumor necrosis factor (TNF)family of proteins includes several soluble and membrane proteins that share structural homologies.All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions ,select the term listed in options A-E that best matches it.
Expressed on macrophages and B lymphocytes,this receptor plays an important role in the helper T cell-mediated effector functions.

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin/TNF-b

Question 7

For each of the following descriptions of a chemokine or chemokine receptor,select the chemokine or chemokine receptor (A-G)that most closely matches it.
Binds to interleukin-8

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CXCL13

Question 8

For each of the descriptions of a biologic function in questions ,select the T cell-derived cytokine (A-E)that matches it.
Stimulates expression of class II MHC on various cell types

A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)IL-17

Question 9

For each of the descriptions of a biologic function in questions ,select the T cell-derived cytokine (A-E)that matches it.
Induces B cell isotype switching to IgE production

A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)IL-17

Question 10

For each of the descriptions of a biologic function in questions ,select the T cell-derived cytokine (A-E)that matches it.
Inhibits proliferation and differentiation of T cells and the activation of macrophages

A)Interferon-g
B)Interleukin (IL)-4
C)IL-5
D)Transforming growth factor-b
E)IL-17

Question 11

For each of the following descriptions of a chemokine or chemokine receptor,select the chemokine or chemokine receptor (A-G)that most closely matches it.
Mediates neutrophil recruitment into tissues

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CXCL13

Question 12

For each of the following descriptions of a chemokine or chemokine receptor,select the chemokine or chemokine receptor (A-G)that most closely matches it.
Binds chemokines important in T cell recruitment into peripheral inflammatory sites

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CXCL13

Question 13

The tumor necrosis factor (TNF)family of proteins includes several soluble and membrane proteins that share structural homologies.All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions ,select the term listed in options A-E that best matches it.
Expressed on osteoclasts,this receptor is important in remodeling bone.

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin/TNF-b

Question 14

The tumor necrosis factor (TNF)family of proteins includes several soluble and membrane proteins that share structural homologies.All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions ,select the term listed in options A-E that best matches it.
Produced by T cells and binds to the same receptors as does TNF-a produced by macrophages

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin/TNF-b

Question 15

For each of the following descriptions of a chemokine or chemokine receptor,select the chemokine or chemokine receptor (A-G)that most closely matches it.
Important mediator of inflammatory component of immediate hypersensitivity reactions

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CXCL13

Question 16

For each of the following descriptions of a chemokine or chemokine receptor,select the chemokine or chemokine receptor (A-G)that most closely matches it.
Important in dendritic cell and T cell localization in lymph nodes

A)CXCL8 (IL-8)
B)CXCL10 (IP-10)
C)CCL19 (ELC)
D)CCL11 (Eotaxin)
E)CCR5
F)CXCR1
G)CXCL13

Question 17

The tumor necrosis factor (TNF)family of proteins includes several soluble and membrane proteins that share structural homologies.All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions ,select the term listed in options A-E that best matches it.
Expressed on many cells types,its cytoplasmic tail includes a death domain,binds TNF-receptor associated death domain (TRADD),and initiates a pro-apoptotic signaling cascade.

A)TNF-RI
B)CD40
C)Fas ligand
D)RANK
E)Lymphotoxin/TNF-b