Deck 18: Amines and Amides

Question 1

Amines contain the element

A) nitrogen.
B) oxygen.
C) sulfur.
D) astatine.
E) arginine.

Answer 1

nitrogen.

Question 2

Which of the following compounds CANNOT form hydrogen bonds with water?

A) CH₃CH?CH₃
B) CH₃CH?OH
C) $\begin{array} { c } \mathrm { O } \\\mathrm { || } \\\mathrm { CH } _ { 3 } \mathrm { C } \mathrm { OH }\end{array}$
D)

$\begin{array} { c } \mathrm { O } \\\mathrm { || } \\\quad\mathrm { CH } _ { 3 } \mathrm { C } \mathrm { OCH }_ { 3 } \end{array}$
E) CH₃CH?NH?

Answer 2

CH₃CH?CH₃

Question 3

Which of the following compounds CANNOT form hydrogen bonds with water?

A) (CH3CH₂)₂NH
B) CH3CH₂OH
C) (CH3CH₂)3N
D) CH3CH₂NH₂
E) All of the compounds above are capable of forming hydrogen bonds with water.

Answer 3

(CH3CH₂)3N

Question 4

What is the name of this compound?

A) 1-methyl-5-bromoaniline
B) N-methyl-3-bromoaniline
C) N-methyl-p-bromoaniline
D) 1-bromo-3-N-methylamine benzene
E) 1-bromo-3-N-methyl aniline

Question 5

Name the following compound.

A) ethyl amine
B) dimethyl ether
C) methanal
D) 1-methanoate
E) dimethyl amine

Question 6

What prefix is used to show that a small alkyl group is attached to the nitrogen of aniline and not to the aromatic ring?

A) N-
B) C-
C) Roman numerals
D) Greek letters
E) iso-

Question 7

The compound CH₃CH₂NHCH₃ is classified as a

A) primary amine.
B) secondary amine.
C) tertiary amine.
D) quaternary amine.
E) hydrated amine.

Question 8

Amines can form __________ bonds with other molecules.

A) oxygen
B) hydrogen
C) nonpolar
D) metallic
E) triple

Question 9

Which of the following compounds is an amine?

A) (CH3CH₂)₂NH
B) CH3CH₂CH₂CH₂CO₂CH3
C) CH3CH₂CH₂CH₂-O-CH₂CH₂CH3
D) CH3CH=O
E) CH3COCH3

Question 10

What relation does the boiling point of an amine have to a similar hydrocarbon?

A) higher
B) lower
C) very similar

Question 11

How many alkyl substituents does N-ethyl-N-methylaniline have?

A) one
B) two
C) three
D) eight
E) none

Question 12

When naming amines according to the IUPAC system, the -e in the corresponding alkane is replaced with

A) -amide.
B) -amine.
C) -ine.
D) -ide.
E) -ane.

Question 13

What is the name of this compound? $$\begin{array} { c } \quad \quad\mathrm { CH } _ { 3 } \mathrm { NCH } _ { 2 } \mathrm { CH } _ { 3 } \\\mathrm { |} \\\quad\mathrm { CH } _ { 3 }\end{array}$$

A) trimethylamine
B) diethylamine
C) ethylmethylamine
D) ethylmethylnitride
E) ethyldimethylamine

Question 14

Aminobenzene is properly known as

A) toluene.
B) aniline.
C) amidine.
D) histidine.
E) phenylamine.

Question 15

Aniline is a(n)

A) primary aromatic amine.
B) secondary aromatic amine.
C) heterocyclic amine.
D) aliphatic amine.
E) tertiary amine.

Question 16

When ethylamine dissolves in water, a solution of __________ is produced.

A) ammonia
B) ethylammonium hydroxide
C) ethylamine
D) ethylhydroxide
E) ethylhydroxylate

Question 17

In what kind of amine is the nitrogen directly bonded to two carbon atoms?

A) primary
B) secondary
C) tertiary
D) quaternary
E) amide

Question 18

The compound CH₃CH₂NH₂ is classified as a

A) primary amine.
B) secondary amine.
C) tertiary amine.
D) quaternary amine.
E) hydrated amine.

Question 19

Which of the following represents the complete neutralization of N,N-dimethylamine?

A)
B)
C)
D)
E)

Question 20

Diethylamine and HCl react to produce

A) diethyl chloride.
B) diethylammonium chloride.
C) ethylammonium chloride.
D) ammonium chloride.
E) butylammonium chloride.

Question 21

Procaine and Lidocaine were developed by modifying the structure of

A) cocaine.
B) nicotine.
C) harmaline.
D) meperidine.
E) caffeine.

Question 22

In what form are amine-containing drugs often administered?

A) free base
B) sodium salt
C) amine salt
D) water solution
E) oil solution

Question 23

When acetic acid reacts with ammonia, NH3, the reaction called amidation yields

A) acetamine.
B) ammonium acetate.
C) ethylammonium hydroxide.
D) amino acetate.
E) acetamide.

Question 24

What is the name of this compound?

A) 1-ethylbenzamide
B) N,N-dimethylbenzamide
C) 2-ethylbenzamide
D) N-ethylbenzamide
E) ethylaminobenzoic acid

Question 25

Choline is a quaternary ammonium compound with a __________ charge on the nitrogen.

A) positive
B) negative
C) zero
D) neutral
E) double

Question 26

Identify the heterocyclic amine in the choices below.

A) diphenhydramine
B) pyrrolidine
C) adrenaline
D) methylamine
E) cholesterol

Question 27

One name for this compound is

A) N-ethylpropanamide.
B) N-ethylacetamide.
C) pentanamide.
D) N,N-diethylacetamide.
E) ethylpropionamide.

Question 28

What is the major functional group in the following compound?

A) ketone
B) carboxylic acid
C) ester
D) amine
E) amide

Question 29

Among the choices below, identify the heterocyclic amine found in DNA.

A) piperidine
B) pyridine
C) pyrrole
D) purine
E) imidazole

Question 30

What kind of amine can NOT form hydrogen bonds?

A) primary
B) secondary
C) tertiary
D) aromatic
E) substituted

Question 31

Physiologically active nitrogen-containing compounds produced by plants are called

A) aromatics.
B) alkaloids.
C) esters.
D) polymers.
E) ethers.

Question 32

The amide formed in the reaction of benzoic acid and ethylamine is

A)
B)
C)
D)
E)

Question 33

Nicotine, coniine, quinine, atropine, and morphine are all examples of

A) ethers.
B) esters.
C) carboxylic acids.
D) alkaloids.
E) amides.

Question 34

What functional group is always found in alkaloids (such as caffeine, nicotine, and digitalis)?

A) amide
B) acid
C) ether
D) amine
E) ester

Question 35

The odor of an amine can be neutralized with

A) water.
B) acids.
C) bases.
D) detergents.
E) solvents.

Question 36

Amines are

A) Bronsted-Lowry bases.
B) Bronsted-Lowry acids.
C) neutral in water solution.
D) unreactive.

Question 37

What are alkaloids?

A) physiologically active nitrogen compounds derived from plants
B) anesthetics found in plants
C) flavoring agents found in fruits and vegetables
D) preservatives found in animal tissue
E) natural steroids

Question 38

Which of the following is NOT an alkaloid?

A) nicotine
B) caffeine
C) diethylamine
D) quinine
E) cocaine

Question 39

What kind of pharmacologic activity is found in the amines Procaine® and Lidocaine®?

A) stimulant
B) anesthetic
C) local anesthetic
D) disinfectant
E) fungicide

Question 40

Cyclic compounds that contain a nitrogen atom are called

A) carbocyclic compounds.
B) aromatic compounds.
C) heterocyclic compounds.
D) homocyclic compounds.

Question 41

With the correct choice of acid, acid hydrolysis of acetamide could produce

A) acetic acid and ammonium chloride.
B) acetic acid and methylamine.
C) ethanol and ammonia.
D) acetaldehyde and ammonium hydroxide.
E) formic acid and ethylamine.

Question 42

The amine functional group is rarely found in pharmacologically active compounds.

Question 43

Amides are derivatives of __________ and __________.

A) amines; esters
B) amines; carboxylic acids
C) alkanes; amines
D) carboxylic acids; alcohols
E) alcohols; carboxylic acids

Question 44

A deficiency of which amine is responsible for the signs and symptoms of Parkinson's disease?

A) histamine
B) dopamine
C) epinephrine
D) diphenhydramine
E) methedrine

Question 45

Ethylmethylamine is a tertiary amine.

Question 46

What pharmacologically active amine is responsible for the signs and symptoms encountered in an allergic reaction?

A) histamine
B) epinephrine
C) diphenhydramine
D) phenylephrine
E) dopamine

Question 47

Which of the following is the reaction for the acid hydrolysis of N-methylacetamide?

A)
B)
C)
D)
E)

Question 48

Amides having fewer than __________ carbons are generally water soluble.

A) five
B) six
C) ten
D) eleven
E) twelve

Question 49

The reaction of butanoic acid and dimethylamine gives

A) N-methylbutanamide.
B) N-ethylbutanamide.
C) N,N-dimethylbutanamide.
D) N,N-methylbutanamine.
E) N-methylbutanamine.

Question 50

What kind of compound is urea?

A) ester
B) acid
C) amide
D) ketone
E) amine

Question 51

Which chemical class does phenobarbital belong to?

A) ester
B) amine
C) amide
D) alkane
E) ether

Question 52

In the formation of N-ethylacetamide, the reactant(s) is(are)

A) acetic acid and dimethylamine.
B) diethylamine.
C) acetamide and ethanol.
D) acetic acid and ethylamine.
E) ethanol and ethylamine.

Question 53

Which of the following is the reaction for the base hydrolysis of N-ethylformamide?

A)
B)
C)
D)
E)

Question 54

Aniline is a primary amine.

Question 55

In response to allergic reactions or injury to cells, the body increases the production of

A) diphenhydramine.
B) antihistamine.
C) histamine.
D) epinephrine.
E) dopamine.

Question 56

With the correct choice of acid, the product(s) of the acid hydrolysis of N-methylbenzamide could be

A) formic acid and aniline.
B) methanol and benzoic acid.
C) benzoic acid and ethylamine.
D) benzoic acid and methylammonium chloride.
E) formic acid, phenol, and ammonia.

Question 57

A neurotransmitter

A) transmits neurons
B) transmits neutrons
C) transmits a nerve impulse
D) signals loss of appetite
E) transmits ideas from person to person

Question 58

Aniline is the IUPAC approved name for aminobenzene.

Question 59

What is the chemical classification of the barbiturate sedatives?

A) cyclic amides
B) cyclic ethers
C) cyclic amines
D) cyclic esters
E) cyclic acids

Question 60

Which of the following is NOT a neurotransmitter?

A) histamine
B) epinephrine
C) glutamate
D) pyridine
E) serotonin

Question 61

Primary amines contain two carbon-containing groups bonded to the nitrogen atom.

Question 62

Quinine is an alkaloid used for treatment of malaria.

Question 63

Amine salts are odorless and usually highly water soluble.

Question 64

Amines do not ionize in water.

Question 65

Urea is one end product of protein metabolism in humans.

Question 66

Nicotine is a pharmacologically active aromatic amide.

Question 67

Crack cocaine is produced by the neutralization and extraction of cocaine from its hydrochloride salt.

Question 68

The amide group is often found in pharmacologically active substances.

Question 69

Amines are mostly ionized in water.

Question 70

Pyrimidine derivatives are found in DNA.

Question 71

Heterocyclic amines contain a nitrogen atom in a ring.

Question 72

Hydrogen bonds in amines are weaker than those in alcohols.

Question 73

Amines do not form hydrogen bonds.

Question 74

Amine salts are usually liquid at room temperature.

Question 75

Aspartame is a sweetener made from corn.

Question 76

Amines with more that six carbon atoms are soluble in water.

Question 77

Caffeine is not an alkaloid.

Question 78

Atropine and cocaine are used in the diagnosis of eye diseases.

Question 79

Amines act as weak acids by accepting protons from water.

Question 80

Meperidine is a synthetic compound developed from morphine.