Deck 18: Amines and Amides

Question 1

Aniline is a(n)

A)primary aromatic amine.
B)secondary aromatic amine.
C)heterocyclic amine.
D)aliphatic amine.
E)tertiary amine.

Answer 1

primary aromatic amine.

Question 2

Which of the following compounds CANNOT form hydrogen bonds with water?

A)(CH₃- CH₂)₂NH
B)CH₃- CH₂ - OH
C)(CH₃- CH₂)₃N
D)CH₃- CH₂ - NH₂
E)All of the compounds above are capable of forming hydrogen bonds with water.

Answer 2

(CH₃- CH₂)₃N

Question 3

Aminobenzene is properly known as

A)toluene.
B)aniline.
C)amidine.
D)histidine.
E)phenylamine.

Answer 3

aniline.

Question 4

What is the name of this compound?

A)1-methyl-5-bromoaniline
B)N-methyl-3-bromoaniline
C)N-methyl-p-bromoaniline
D)1-bromo-3-N-methylamine benzene
E)1-bromo-3-N-methyl aniline

Question 5

When naming amines according to the IUPAC system, the -e in the corresponding alkane is replaced with

A)-amide.
B)-amine.
C)-ine.
D)-ide.
E)-ane.

Question 6

What is the IUPAC name of the following compound?

A)propyl amine
B)butyl amine
C)amine butane
D)1-aminobutane
E)1-aminopropane

Question 7

Name the following compound.

A)ethyl amine
B)dimethyl ether
C)methanal
D)1-methanoate
E)dimethyl amine

Question 8

When ethylamine dissolves in water, a solution of ________ is produced.

A)ammonia
B)ethylammonium hydroxide
C)ethylamine
D)ethylhydroxide
E)ethylhydroxylate

Question 9

What prefix is used to show that a small alkyl group is attached to the nitrogen of aniline and not to the aromatic ring?

A)N-
B)C-
C)Roman numerals
D)Greek letters
E)iso-

Question 10

Which of the following compounds is an amine?

A)(CH₃
- CH2)₂
NH
B)CH₃
- CH2 - CH2 - CH2 - CO2 - CH₃
C)CH₃
- CH2 - CH2 - CH2 - O - CH2 - CH2 - CH₃
D)CH₃
- CH = O
E)CH₃
- CO - CH₃

Question 11

The compound CH₃ - CH2 - NH - CH₃ is classified as a

A)primary amine.
B)secondary amine.
C)tertiary amine.
D)quaternary amine.
E)hydrated amine.

Question 12

The compound CH₃ - CH2 - NH2 is classified as a

A)primary amine.
B)secondary amine.
C)tertiary amine.
D)quaternary amine.
E)hydrated amine.

Question 13

What is the name of this compound? CH₃ - N - CH2 - CH₃ | CH₃

A)trimethylamine
B)diethylamine
C)ethylmethylamine
D)ethylmethylnitride
E)ethyldimethylamine

Question 14

Amines contain the element

A)nitrogen.
B)oxygen.
C)sulfur.
D)astatine.
E)arginine.

Question 15

Which of the following compounds CANNOT form hydrogen bonds with water?

A)CH₃- CH₂ - CH₃
B)CH₃- CH₂ - OH
C)

D)
E)CH₃- CH₂ - NH₂

Question 16

In what kind of amine is the nitrogen directly bonded to two carbon atoms?

A)primary
B)secondary
C)tertiary
D)quaternary
E)amide

Question 17

Diethylamine and HCl react to produce

A)diethyl chloride.
B)diethylammonium chloride.
C)ethylammonium chloride.
D)ammonium chloride.
E)butylammonium chloride.

Question 18

How many alkyl substituents does N-ethyl-N-methylaniline have?

A)one
B)two
C)three
D)eight
E)none

Question 19

Which of the following represents the complete neutralization of N,N-dimethylamine?

A)CH₃
NH + H2O → CH₃
NH2+ + OH-
| |
CH₃
CH₃
B)CH₃
NH + NaOH → CH₃
N-Na+ + H2O
| |
CH₃
CH₃
C)CH₃
NH + HCl → CH₃
NH2 + CH₃
Cl
|
CH₃
D)CH₃
NH + H2O → CH₃
OH + CH₃
NH₂
|
CH₃
E)CH₃
NH + HCl → CH₃
NH2+ + Cl-
| |
CH₃
CH₃

Question 20

What is the common name of the following compound?

A)ethyl propyl amine
B)diethyl amine
C)trimethyl amine
D)propyl amino
E)dipropyl amine

Question 21

What functional group is always found in alkaloids (such as caffeine, nicotine, and digitalis)?

A)amide
B)acid
C)ether
D)amine
E)ester

Question 22

The amide formed in the reaction of benzoic acid and ethylamine is

A)
B)
C)
D)
E)

Question 23

Amines can form ________ bonds with other molecules.

A)oxygen
B)hydrogen
C)nonpolar
D)metallic
E)triple

Question 24

Cyclic compounds that contain a nitrogen atom are called

A)carbocyclic compounds.
B)aromatic compounds.
C)heterocyclic compounds.
D)homocyclic compounds.

Question 25

Nicotine, coniine, quinine, atropine, and morphine are all examples of

A)ethers.
B)esters.
C)carboxylic acids.
D)alkaloids.
E)amides.

Question 26

In what form are amine-containing drugs often administered?

A)free base
B)sodium salt
C)ammonium salt
D)water solution
E)oil solution

Question 27

Procaine and Lidocaine were developed by modifying the structure of

A)cocaine.
B)nicotine.
C)harmaline.
D)meperidine.
E)caffeine.

Question 28

What relation does the boiling point of an amine have to a similar hydrocarbon?

A)higher
B)lower
C)very similar

Question 29

What is the major functional group in the following compound? O CH₃ - C - NH - CH₃

A)ketone
B)carboxylic acid
C)ester
D)amine
E)amide

Question 30

Identify the heterocyclic amine in the choices below.

A)diphenhydramine
B)pyrrolidine
C)adrenaline
D)methylamine
E)cholesterol

Question 31

Among the choices below, identify the heterocyclic amine found in DNA.

A)piperidine
B)pyridine
C)pyrrole
D)purine
E)imidazole

Question 32

What kind of pharmacologic activity is found in the amines Procaine and Lidocaine?

A)stimulant
B)anesthetic
C)local anesthetic
D)disinfectant
E)fungicide

Question 33

When acetic acid reacts with ammonia, NH₃ , the reaction called amidation yields

A)acetamine.
B)ammonium acetate.
C)ethylammonium hydroxide.
D)amino acetate.
E)acetamide.

Question 34

Amines are

A)Bronsted-Lowry bases.
B)Bronsted-Lowry acids.
C)neutral in water solution.
D)unreactive.

Question 35

Physiologically active nitrogen-containing compounds produced by plants are called

A)aromatics.
B)alkaloids.
C)esters.
D)polymers.
E)ethers.

Question 36

Choline is a quaternary ammonium compound with a ________ charge on the nitrogen.

A)positive
B)negative
C)zero
D)neutral
E)double

Question 37

The odor of an amine can be neutralized with

A)water.
B)acids.
C)bases.
D)detergents.
E)solvents.

Question 38

Which of the following is NOT an alkaloid?

A)nicotine
B)caffeine
C)diethylamine
D)quinine
E)cocaine

Question 39

What kind of amine can NOT form hydrogen bonds?

A)primary
B)secondary
C)tertiary
D)aromatic
E)substituted

Question 40

What are alkaloids?

A)physiologically active nitrogen compounds derived from plants
B)anesthetics found in plants
C)flavoring agents found in fruits and vegetables
D)preservatives found in animal tissue
E)natural steroids

Question 41

In the formation of N-ethylacetamide, the reactant(s) is(are)

A)acetic acid and dimethylamine.
B)diethylamine.
C)acetamide and ethanol.
D)acetic acid and ethylamine.
E)ethanol and ethylamine.

Question 42

Which of the following is NOT a neurotransmitter?

A)histamine
B)epinephrine
C)glutamate
D)pyridine
E)serotonin

Question 43

What kind of compound is urea?

A)ester
B)acid
C)amide
D)ketone
E)amine

Question 44

With the correct choice of acid, acid hydrolysis of acetamide could produce

A)acetic acid and ammonium chloride.
B)acetic acid and methylamine.
C)ethanol and ammonia.
D)acetaldehyde and ammonium hydroxide.
E)formic acid and ethylamine.

Question 45

What is the chemical classification of the barbiturate sedatives?

A)cyclic amides
B)cyclic ethers
C)cyclic amines
D)cyclic esters
E)cyclic acids

Question 46

Amides having fewer than ________ carbons are generally water soluble.

A)five
B)six
C)ten
D)eleven
E)twelve

Question 47

The reaction of butanoic acid and dimethylamine gives

A)N-methylbutanamide.
B)N-ethylbutanamide.
C)N,N-dimethylbutanamide.
D)N,N-methylbutanamine.
E)N-methylbutanamine.

Question 48

Which of the following is the reaction for the acid hydrolysis of N-methylacetamide?

A) O O
CH₃
- C - NH - CH₃
+ H2O → CH₃
- C - NH2 + CH₃
OH
B)O O
H C - NH - CH₃
+ H2O → H C - NH2 + CH₃
OH
C) O O
CH₃
- C - NH - CH₃
+ H2O + HCl → CH₃
- C - NH₃
+Cl- + CH₃
OH
D)O O
H C - NH - CH₃
+ H2O + HCl → H C - NH₃
+Cl- + CH₃
OH
E) O O
CH₃
- C - NH - CH₃
+ H2O + HCl → CH₃
- C OH + CH₃
NH₃
+Cl-

Question 49

A deficiency of which amine is responsible for the signs and symptoms of Parkinson's disease?

A)histamine
B)dopamine
C)epinephrine
D)diphenhydramine
E)methedrine

Question 50

Which chemical class does phenobarbital belong to?

A)ester
B)amine
C)amide
D)alkane
E)ether

Question 51

With the correct choice of acid, the product(s) of the acid hydrolysis of N-methylbenzamide could be

A)formic acid and aniline.
B)methanol and benzoic acid.
C)benzoic acid and ethylamine.
D)benzoic acid and methylammonium chloride.
E)formic acid, phenol, and ammonia.

Question 52

A neurotransmitter

A)transmits neurons.
B)transmits neutrons.
C)transmits a nerve impulse.
D)signals loss of appetite.
E)transmits ideas from person to person.

Question 53

Amides are derivatives of ________ and ________.

A)amines; esters
B)amines; carboxylic acids
C)alkanes; amines
D)carboxylic acids; alcohols
E)alcohols; carboxylic acids

Question 54

In response to allergic reactions or injury to cells, the body increases the production of

A)diphenhydramine.
B)antihistamine.
C)histamine.
D)epinephrine.
E)dopamine.

Question 55

Aniline is the IUPAC approved name for aminobenzene.

Question 56

What is the name of this compound?

A)1-ethylbenzamide
B)N,N-dimethylbenzamide
C)2-ethylbenzamide
D)N-ethylbenzamide
E)ethylaminobenzoic acid

Question 57

Aniline is a primary amine.

Question 58

One name for this compound is O CH₃ - CH2 - C - NH - CH2 - CH₃

A)N-ethylpropanamide.
B)N-ethylacetamide.
C)pentanamide.
D)N,N-diethylacetamide.
E)ethylpropionamide.

Question 59

Which of the following is the reaction for the base hydrolysis of N-ethylformamide?

A)O O
H C - NH - CH2CH₃
+ NaOH → H C OH + CH₃
CH2 - NH2-Na+
B)O O
H C - NH - CH2CH₃
+ NaOH → H C O-Na+ + CH₃
CH2 - NH2
C)O O
H C - NH - CH2CH₃
+ NaOH → H C O-Na+ + NH₃
+ CH₃
CH₃
D)O O
H C - NH - CH2CH₃
+ NaOH → H C O-Na+ + CH₃
- NH - CH₃
E)O
H C - NH - CH2CH₃
+ NaOH → CH₃
CH2 - NH2 + NaHCO2

Question 60

What pharmacologically active amine is responsible for the signs and symptoms encountered in an allergic reaction?

A)histamine
B)epinephrine
C)diphenhydramine
D)phenylephrine
E)dopamine

Question 61

Caffeine is not an alkaloid.

Question 62

Amines with more that six carbon atoms are soluble in water.

Question 63

Amines do not form hydrogen bonds.

Question 64

Ethylmethylamine is a tertiary amine.

Question 65

The amine functional group is rarely found in pharmacologically active compounds.

Question 66

Amines are mostly ionized in water.

Question 67

Atropine and cocaine are used in the diagnosis of eye diseases.

Question 68

Pyrimidine derivatives are found in DNA.

Question 69

Nicotine is a pharmacologically active aromatic amide.

Question 70

Ammonium salts are odorless and usually highly water soluble.

Question 71

Amines do not ionize in water.

Question 72

Crack cocaine is produced by the neutralization and extraction of cocaine from its hydrochloride salt.

Question 73

Ammonium salts are usually liquid at room temperature.

Question 74

Hydrogen bonds in amines are weaker than those in alcohols.

Question 75

Meperidine is a synthetic compound developed from morphine.

Question 76

Primary amines contain two carbon-containing groups bonded to the nitrogen atom.

Question 77

The compound shown is a tertiary amine.

Question 78

Amines act as weak acids by accepting protons from water.

Question 79

Quinine is an alkaloid used for treatment of malaria.

Question 80

Heterocyclic amines contain a nitrogen atom in a ring.