Deck 11: Malignant Disorders of White Blood Cells

Question 1

Fluid and diuretic therapy are used in the management of plasma cell myeloma to

A) reduce the rate of bone destruction.
B) dilute plasma cells in the bloodstream.
C) prevent damage to renal tubules.
D) improve cardiac function.

Answer 1

prevent damage to renal tubules.

Question 2

J.B. is a 12-year-old boy with ALL. As part of J.B.'s treatment, he must undergo several weeks of chemotherapy. The most serious complication of chemotherapy is

A) nausea and vomiting.
B) anemia.
C) alopecia.
D) immunosuppression.

Answer 2

immunosuppression.

Question 3

Nearly all cases of which form of leukemia demonstrate the presence of the Philadelphia chromosome?

A) ALL
B) CLL
C) AML
D) CML

Answer 3

CML

Question 4

The major cause of death from leukemic disease is

A) infection.
B) malnutrition.
C) hypovolemic shock.
D) kidney failure.

Question 5

Chemotherapy is the main form of treatment for various types of leukemia.

Question 6

Low-grade forms of lymphoma generally have a poorer prognosis than high-grade forms.

Question 7

While in the hospital for management of ALL, J.B. developed severe thrombocytopenia. The most appropriate action for this condition would be

A) anticoagulant therapy.
B) chemotherapy.
C) activity restriction.
D) isolation.

Question 8

Polycythemia vera is a myeloid neoplasm.

Question 9

Spontaneous conversion to acute myeloid leukemia (AML) may occur with polycythemia vera, chronic myeloid leukemia, and essential thrombocythemia.

Question 10

Immunoglobulins produced by malignant plasma cells are monoclonal.

Question 11

Plasma cell myeloma is a myeloid neoplasm.

Question 12

J.B. is a 12-year-old boy with acute lymphoblastic leukemia (ALL). Manifestations of J.B.'s leukemia prior to treatment would include all of the following except

A) anemia.
B) leukocytosis.
C) leukopenia.
D) thrombocytopenia.

Question 13

Hodgkin disease is a lymphoid neoplasm.

Question 14

Which of the following types of leukemia primarily affects children?

A) ALL
B) CLL
C) AML
D) CML

Question 15

Leukemia is usually manifested by an elevated white blood cell (WBC) count.

Question 16

The Philadelphia chromosome is a balanced chromosome translocation that forms a new gene called

A) bcr-abl.
B) Rb.
C) p53.
D) ARA-c.

Question 17

The difference between leukemia and lymphoma is that of disease stage.

Question 18

In general, the best prognosis for long-term disease-free survival occurs with

A) ALL.
B) CLL.
C) AML.
D) CML.

Question 19

Non-Hodgkin lymphoma tends to spread in a predictable pattern.

Question 20

A 58-year-old woman is seen in the clinic for complaints of severe back pain. Her chest x-ray demonstrates generalized bone demineralization and compression fracture. Blood studies demonstrate elevated calcium levels. The most likely diagnosis is

A) leukemia.
B) plasma cell myeloma.
C) Hodgkin disease.
D) back trauma.

Question 21

A diagnostic laboratory finding in plasma cell myeloma is

A) Bence Jones proteins in the urine.
B) decreased platelet count.
C) increased IgM antibody titer.
D) elevated blood glucose levels.

Question 22

Burkitt lymphoma is most closely associated with

A) Epstein-Barr virus.
B) radiation exposure.
C) immunodeficiency syndromes.
D) a history of cigarette smoking.

Question 23

All of the following viruses have been implicated as cancer-causing agents except _____ virus.

A) Epstein-Barr
B) human T-cell leukemia
C) human immunodeficiency
D) herpes

Question 24

Which of the following groups of clinical findings describes the typical presentation of ALL?

A) Pain in long bones, infection, fever, bruising
B) Vertebral fracture, hypercalcemia, bone pain
C) Elevated WBC count found on routine exam, asymptomatic
D) Painless enlarged cervical lymph node, fever, weight loss

Question 25

Which of the following is a correct definition of complete remission (CR) of leukemia?

A) CR is the absence of leukemic cells in the blood.
B) CR is less than 5% blasts in marrow and normal CBC values.
C) CR is absence of leukemic cells regardless of CBC values.
D) CR is less than 5% leukemic cells in the blood.

Question 26

Autologous stem cell transplantation is a procedure in which

A) there is a high rejection rate.
B) stem cells are transferred to the patient from an HLA-matched donor.
C) stem cells are transferred to the patient from an identical twin.
D) stem cells are harvested from the patient and then returned to the same patient.