Deck 9: Inflammation and Immunity

Question 1

Antigen-specific receptors on the surfaces of B and T cells are produced

A) in response to interferons.
B) by MHC genes.
C) in response to specific antigens.
D) randomly by genetic recombination.

Answer 1

randomly by genetic recombination.

Question 2

Clonal expansion of B lymphocytes upon first exposure to antigen requires T helper stimulation.

Answer 2

True

Question 3

Which of the following is not a function of T lymphocytes?

A) Antibody synthesis
B) Interleukin-2 production
C) Cell lysis
D) Stimulation of B cells

Answer 3

Antibody synthesis

Question 4

Which of the following immune reactions does not require participation by specific immune cells (lymphocytes)?

A) Activation of complement cascade via the classical pathway
B) Mast cell degranulation in response to antigen
C) Phagocytosis of antigen by macrophage
D) Type IV hypersensitivity reaction

Question 5

Antigen-presenting cells function to

A) display foreign antigen on their cell surfaces bound to MHC.
B) stimulate cytokine production by macrophages.
C) phagocytose and degrade foreign antigens.
D) initiate the complement cascade by way of the alternative pathway.

Question 6

MHC I are present on the surface of all nucleated cells, whereas MHC II are present on the surface of specialized antigen-presenting cells.

Question 7

Cytotoxic lymphocytes are activated by recognition and binding of antigen in association with major histocompatibility complex type I (MHC I) proteins.

Question 8

The "classical pathway" for activation of the complement cascade requires

A) activated T cells.
B) macrophages.
C) exposed foreign surfaces.
D) antibodies.

Question 9

An example of active immunity would be

A) vaccination with polio vaccine.
B) administration of immune globulin.
C) immune protection passed through the placenta.
D) antibiotic administration for strep throat.

Question 10

The most prevalent antibody class in the body is IgM.

Question 11

The macrophage has little importance in immune function other than its role in phagocytosis.

Question 12

Which of the following cell types is thought to dampen the immune response?

A) T helper cells
B) Neutrophils
C) Regulatory lymphocytes
D) Macrophages

Question 13

The "constant" region of an antibody molecule determines antigen specificity.

Question 14

For T helper cells to bind to a foreign antigen, the antigen must first be processed by an antigen-presenting cell.

Question 15

Which of the following cell types does not evolve from the myelocytic pathway?

A) Red blood cells
B) Monocytes
C) Granulocytes
D) Natural killer cells

Question 16

Inflammation is said to be nonspecific because

A) specific immune cells do not participate.
B) the inflammatory reaction is similar regardless of cause.
C) it contributes minimally to immune functions.
D) it is a poorly understood phenomenon.

Question 17

T lymphocytes are activated primarily by free viruses.

Question 18

Each B lymphocyte is able to bind to and produce antibody against only one specific antigen.

Question 19

Tolerance to self-tissues only occurs during embryogenesis.

Question 20

All of the following are actions of antibodies except

A) antigen agglutination.
B) antigen precipitation.
C) opsonization.
D) phagocytosis.

Question 21

Match the following descriptions with the terms below (letters may be used only once).
Mast cells

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 22

Interleukin-1, interleukin-6, and tumor necrosis factor $\alpha$ are inflammatory cytokines secreted by

A) plasma cells.
B) neutrophils.
C) lymphocytes.
D) macrophages.

Question 23

The mononuclear phagocyte system consists of

A) monocytes and fixed tissue macrophages.
B) specifically activated lymphocytes.
C) bone marrow stem cells.
D) antibody-secreting plasma cells.

Question 24

The membrane attack complex formed by complement is similar in structure and function to

A) CD4⁺.
B) granzymes.
C) gp120.
D) perforin.

Question 25

Which of the following clinical findings is most indicative of an acute bacterial infection?

A) Increased neutrophil bands
B) Elevated temperature
C) Elevated erythrocyte sedimentation rate
D) Elevated WBC count

Question 26

Match the following descriptions with the terms below (letters may be used only once).
Eosinophils

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 27

Match the following descriptions with the terms below (letters may be used only once).
Complement

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 28

Clonal deletion refers to

A) proliferation of plasma cells in response to antigen.
B) destruction of self-reacting B and T lymphocytes.
C) desensitization therapy for allergic reactivity.
D) T-suppressor activity.

Question 29

Match the following descriptions with the terms below (letters may be used only once).
Dendritic cell

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 30

Match the following descriptions with the terms below (letters may be used only once).
Neutrophils

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 31

Match the following descriptions with the terms below (letters may be used only once).
T lymphocytes

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 32

Match the following descriptions with the terms below (letters may be used only once).
Natural killer cells

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 33

Match the following descriptions with the terms below (letters may be used only once).
Monocytes

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 34

In a primary immune response, activated B cells produce mostly

A) IgA.
B) IgG.
C) IgE.
D) IgM.

Question 35

Match the following descriptions with the terms below (letters may be used only once).
Basophils

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 36

Match the following descriptions with the terms below (letters may be used only once).
Cytotoxic T cell

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 37

Match the following descriptions with the terms below (letters may be used only once).
Histiocytes

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell

Question 38

Activation of the complement cascade results in

A) antibody production.
B) inflammation.
C) immunosuppression.
D) autoimmunity.

Question 39

Proteins that are increased in the bloodstream during acute inflammation are called _____ proteins.

A) antibody
B) lymphokine
C) acute phase
D) antiidiotype

Question 40

Match the following descriptions with the terms below (letters may be used only once).
Plasma cells

A)Membrane attack complex
B)Basophil-like cells in tissues
C)Lymphocyte that lacks B/T markers
D)Able to bind IgE (Fc end)
E)Circulating macrophages
F)Fixed tissue macrophages
G)Provide protection against helminths
H)Express CD4 or CD8 markers
I)Make up 90% of circulating granulocytes
J)MHC class I restricted
K)Antibody-producing B cells
L)Antigen-presenting cell