During lagging strand synthesis,it is not uncommon for the DNA polymerase III holoenzyme to dissociate completely from the DNA template for approximately two seconds.

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During lagging strand synthesis, DNA polymerase III holoenzyme remains attached to the DNA template through a sliding clamp mechanism, which ensures processivity. The enzyme does not typically dissociate completely but rather synthesizes short Okazaki fragments before reinitiating synthesis on a new RNA primer.

During Lagging Strand Synthesis,it Is Not Uncommon for the DNA