Signs and symptoms of end-stage renal disease begin to appear when approximately 75% of nephrons have been lost.

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This is correct. End-stage renal disease typically presents when a significant amount of nephrons (the functional units of the kidneys) have been lost, usually around 75%. At this point, the kidneys are no longer able to effectively filter waste and excess fluid from the body, leading to a range of symptoms and complications.

Signs and Symptoms of End-Stage Renal Disease Begin to Appear