Which of the following immunodeficiency diseases is attributed to a genetic defect in enzyme function?

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Severe combined immunodeficiency (SCID) is attributed to a genetic defect in enzyme function, specifically in the enzymes responsible for DNA repair in immune cells. This results in a severe deficiency in T and B cell function, leaving the individual highly susceptible to infections. Selective IgA deficiency, DiGeorge syndrome, and Cushing syndrome are not attributed to genetic defects in enzyme function.

Which of the Following Immunodeficiency Diseases Is Attributed to a Genetic