Sickle cell disease is characterized by the presence of Hb S. Which of the following amino acids is present in Hb S and not present in normal Hb?
A) Valine
B) Glutamic acid
C) Proline
D) Histidine

Question

Quizplus · Accepted Answer

Sickle cell disease is caused by a single point mutation in the β-globin gene, resulting in a substitution of valine for glutamic acid at position 6 of the β-globin chain. Normal hemoglobin (HbA) has a glutamic acid residue at this position.

Sickle Cell Disease Is Characterized by the Presence of Hb