How does the mutation responsible for phenylketonuria affect diet?

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Phenylketonuria is caused by a mutation in the gene that codes for the enzyme phenylalanine hydroxylase, which is responsible for converting the amino acid phenylalanine to tyrosine. Without this enzyme, phenylalanine cannot be metabolized and accumulates in the blood and brain, leading to neurological problems. Therefore, in order to manage phenylketonuria, dietary phenylalanine must be strictly limited or eliminated altogether. Babies born with the condition are given special low-phenylalanine formula and must follow a strict diet throughout their lives.

How Does the Mutation Responsible for Phenylketonuria Affect Diet