The fi chain of adult hemoglobin is composed of 146 amino acids of a known sequence.In comparing the normal fi chain with the fi chain in sickle- cell hemoglobin,what alteration is one likely to find?

Question

Quizplus · Accepted Answer

The alteration likely to be found in the sickle-cell hemoglobin is a substitution of valine for glutamic acid in the sixth position of the fi chain. This substitution results in the abnormal folding of the hemoglobin molecule, leading to sickle-cell anemia.

The Fi Chain of Adult Hemoglobin Is Composed of 146