Which president suffered a major defeat when the Senate refused to ratify the Treaty of Versailles?

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Woodrow Wilson suffered a major defeat when the Senate refused to ratify the Treaty of Versailles. Wilson, who had played a major role in negotiating the Treaty, was unable to convince the Senate to ratify it due to opposition from both Republicans and Democrats, who believed that the Treaty threatened American independence and sovereignty. The Senate's rejection of the Treaty was a significant setback for Wilson's foreign policy agenda, and contributed to his declining popularity and health.

Which President Suffered a Major Defeat When the Senate Refused