Cleft lip or palate is a common congenital midline fissure,or opening,in the lip or palate resulting from the failure of the primary palate to fuse.Multiple genetic and,to a lesser extent,environmental factors may lead to the development of a cleft lip or palate.Which factors are included? (Select all that apply. )

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Alcohol consumption, use of some corticosteroid medications, and maternal cigarette smoking are all known environmental factors that may increase the risk of developing a cleft lip or palate. Female gender and antibiotic use in pregnancy are not known to be associated with increased risk.

Cleft Lip or Palate Is a Common Congenital Midline Fissure,or