In human females the increased prevalence of birth defects in offspring and of infertility after 30 years of age is one indication of

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The increased prevalence of birth defects in offspring and of infertility after 30 years of age in human females is an indication of senescence, the gradual deterioration of physiological function with age. This is not related to iteroparity or semelparity (reproductive strategies that relate to how many times an organism reproduces in its lifetime), middle age (a general stage of life between young adulthood and old age), or reproductive failure (which could have a variety of causes beyond just senescence).

In Human Females the Increased Prevalence of Birth Defects in Offspring