A 60-year-old male presents with GI bleeding and abdominal pain.He reports that he takes NSAIDs daily to prevent heart attack.Tests reveal that he has a peptic ulcer.The most likely cause of this disease is:
A) Increasing subepithelial bicarbonate production
B) Accelerating the H+ (proton) pump in parietal cells
C) Inhibiting mucosal prostaglandin synthesis
D) Stimulating a shunt of mucosal blood flow

Question

Quizplus · Accepted Answer

Use of NSAIDs inhibit prostaglandins and maintenance of the mucosal barrier and decrease bicarbonate secretion.
NSAIDs decrease bicarbonate production.
H.pylori increases hydrogen secretion.
NSAIDs do not affect mucosal blood flow.

A 60-Year-Old Male Presents with GI Bleeding and Abdominal Pain