Apoptosis differs from necrosis in that necrosis

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Necrosis causes cells to swell and burst, leading to inflammation and tissue damage, whereas apoptotic cells shrink and condense and are typically cleared by phagocytes without causing inflammation. Necrosis is often a result of acute injury or infection, whereas apoptosis is a natural process used by the body to remove damaged or unnecessary cells. While both necrosis and apoptosis can cause DNA to fragment, only apoptosis involves a caspase cascade. Necrosis does not require an extracellular signal, as it is typically caused by factors such as hypoxia, physical trauma, or toxins.

Apoptosis Differs from Necrosis in That Necrosis