The phenomenon that can produce high frequencies of deleterious alleles in small, isolated populations is

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The founder effect is a phenomenon that can lead to high frequencies of deleterious alleles in small, isolated populations. This occurs when a new colony is started by a few members of the original population, leading to a reduced genetic variation and a different allele frequency compared to the original population, potentially including harmful alleles.

The Phenomenon That Can Produce High Frequencies of Deleterious Alleles