Prions from One Species Do Not Easily Cause Prion Diseases

Prions from one species do not easily cause prion diseases in animals of a different species.Which of the following may explain why?

A) The host cell needs to have the correct receptor for entry of the Prp^Sc protein.
B) The host needs to have the correct proteases for the proper processing of the PrP^Sc protein.
C) The host cell needs to provide the correct glycosylation pattern on the Prp^Sc protein.
D) The Prp^Sc protein needs to interact with a PrP^C protein with the same amino acid sequence.
E) There are other host related proteins involved in the development of a prion disease.