When a Patient's Adverse Reaction to a Blood Transfusion Is

When a patient's adverse reaction to a blood transfusion is differentiated,which of the following signs and symptoms indicates the presence of an anaphylactic response?

A) Wheezing and chest pain
B) Headache and muscle pain
C) Hypotension and tingling of the extremities
D) Crackles in the lungs and increased central venous pressure