Given that the heavy chain has 100 V regions, 5 D regions, and 20 J regions; that the heavy chain has 200 V regions and 5 J regions; and that IgG has 4 subclasses, how many different specificities can be formed with the kappa light chain and the heavy chain given?

Question

Quizplus · Accepted Answer

The heavy chain can form 100 x 5 x 20 = 100,000 different specificities. The kappa light chain can form 200 x 5 = 1,000 different specificities. The total number of different specificities that can be formed is 100,000 x 1,000 = 100,000,000 = 10^8. Since IgG has 4 subclasses, the total number of different specificities that can be formed is 10^8 x 4 = 4 x 10^8.

Given That the Heavy Chain Has 100 V Regions, 5