Which of the Following Statements BEST Characterizes Many Cancers Such

Which of the following statements BEST characterizes many cancers such as colon cancer?

A) They result from the activation of one critical tumor-suppressor gene.
B) They result when the transition from G₂ to M in the cell cycle is inhibited.
C) They result when DNA replication during the S period of the cell cycle is inhibited.
D) They result from a series of sequential mutations in a number of genes.
E) They result from decreased expression in a series of cellular oncogenes.