Changes in Temperature or PH Can Cause Enzymes to Lose

Changes in temperature or pH can cause enzymes to lose activity. What is a common feature of these two effects?

A) Temperature and pH affect the rate of substrate binding.
B) Temperature and pH change the ionization state of cofactors.
C) Temperature and pH both induce an enzyme to lose its precise three-dimensional shape.
D) Temperature and pH change the activation energy of the reaction.
E) There is no common mechanism of temperature and pH effects on enzyme activity.