The opposite of a disease that does respond to treatment is a disease that is:

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A disease that does not respond to treatment is considered refractory, meaning it is resistant to therapy. Prognosis refers to the predicted outcome of a disease, and therapeutic refers to something that is used to treat or cure a disease. In remission means that a disease is no longer active or causing symptoms, but it does not necessarily indicate whether it responded to treatment or not.

The Opposite of a Disease That Does Respond to Treatment