According to Map 12.3, "The Spice Trade, ca. 100 B.C.E.-1500 C.E.," which cities or countries were most likely to engage in the ever-increasing spice trade?

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The map shows that the spice trade was largely conducted by maritime powers such as India, Southeast Asia, and the Middle East. These regions had easy access to the sea and were able to transport spices to other parts of the world via sea routes.