Patients on long-term drug therapy to control seizures and Parkinson's disease must be watched carefully for signs of:

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Patients on long-term drug therapy for seizures and Parkinson's disease may be susceptible to toxicity due to accumulation of the drugs in their system. It is important to monitor for signs of toxicity, such as changes in mental status, gastrointestinal disturbances, and liver and kidney function. Synergism refers to a combined effect of two drugs that is greater than the sum of their individual effects, tolerance refers to a decrease in response to a drug over time, and antagonism refers to a decreased effect of one drug due to the presence of another drug. While these concepts may also apply to long-term drug therapy, toxicity is most relevant to the management of patients with these conditions.

Patients on Long-Term Drug Therapy to Control Seizures and Parkinson's