What Is the Main Tenet of the Lock-And-Key Model for Drug

What is the main tenet of the lock-and-key model for drug activity?

A) There is a connection between drug structure and drug shape.
B) Only certain biological keys can unlock the potential of a drug.
C) The key to a drug's success is to keep it locked away from stomach acid.
D) The biological lock of an enzyme can be activated by using certain chemical keys.
E) all of the above