Research on brain differences between men who are heterosexual and homosexual, such as LeVay's, has proven fruitful at finding reliable structural differences between them.

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While some studies, including Simon LeVay's 1991 research, have suggested differences in certain brain structures between homosexual and heterosexual men, the findings have not been consistently replicated, and there is no consensus on reliable structural differences. The complexity of human sexuality and the brain makes it difficult to attribute sexual orientation to specific structural differences.

Research on Brain Differences Between Men Who Are Heterosexual and Homosexual