What is the biological basis of the rebound effect that occurs following normal MDMA use?

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MDMA (3,4-methylenedioxymethamphetamine) primarily exerts its effects by increasing the release of neurotransmitters serotonin and dopamine and inhibiting their reuptake, leading to an initial surge in their levels in the brain. However, after the drug's effects wear off, the brain experiences depleted stores of these neurotransmitters, particularly serotonin, which is associated with the mood, energy level, and emotional state of the individual. This depletion is what leads to the "rebound effect" or "comedown," characterized by feelings of depression, lethargy, and emotional sensitivity.

What Is the Biological Basis of the Rebound Effect That