Which of the following situations would support use of positional cloning for disease gene identification?

Question

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Positional cloning is a strategy used to identify disease genes based on their location on a chromosome, rather than the function of the gene or the nature of the disease. It is particularly useful when the pathogenesis of a disease is poorly understood (A), when there are no obvious candidate genes (B), when chromosomal rearrangements point to specific genomic regions (C), and when there are multiple alleles of a gene that could contribute to the disease (D).

Which of the Following Situations Would Support Use of Positional