A patient has two bands on alkaline hemoglobin electrophoresis.One lines up with Hb A and the other is in the S position.Select the best course of action.
A)Report as normal.
B)Report as sickle trait.
C)Report as sickle disease.
D)Confirm sickle gene with tube solubility test.

Question

Quizplus · Accepted Answer

Other abnormal hemoglobins migrate with Hb S on alkaline hemoglobin electrophoresis;Hb D is an example.However,these hemoglobins are not sickling hemoglobins.Therefore,a positive tube solubility test would confirm that the hemoglobin in the S position is Hb S.

A Patient Has Two Bands on Alkaline Hemoglobin Electrophoresis