Cortisol is a natural, short-lived glucocorticoid. Chronic usage of glucocorticoids causes decreased hypothalamic-pituitary-adrenal gland function by disturbing natural glucocorticoid feedback mechanisms. To circumvent this disruption of feedback, a clinician decides to use the exogenous corticosteroid prednisone to decrease chronic inflammation in a dog. What is wrong with this rationale?

Question

Quizplus · Accepted Answer

Exogenous glucocorticoids, like prednisone, also exert feedback on the hypothalamus and pituitary gland, potentially leading to decreased endogenous cortisol production and adrenal gland atrophy with prolonged use. This is contrary to the clinician's rationale to avoid disruption of natural feedback mechanisms.

Cortisol Is a Natural, Short-Lived Glucocorticoid