Question 1

Discuss the cellular factors that might make a drug's spectrum of action narrow rather than broad.

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Question 2

The abbreviation (MBC/MIC/MID)stands for the smallest amount of a drug that will inhibit the growth and reproduction of a pathogen.(Be sure to use all capital letters.)

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Question 3

A (bacteriocidial/bacteriostatic/minimum)concentration of a drug is one at which microbes survive but are not able to grow and reproduce.

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Question 4

Some bacteria develop resistance to groups of drugs because the drugs are all structurally similar to each other; this is a phenomenon known as (cross/multiple/synergistic)resistance.

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Question 5

External infections can be treated by (intramuscular/surface/topical)administration,in which a drug is applied directly to the site of infection.

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Question 6

Why can microbial resistance to antibiotics and other drugs be considered a primarily genetic phenomenon?

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Question 7

Semisynthetic drugs developed to combat resistance are often called (analog/second generation/synergist)drugs.

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Question 8

Antiviral medications frequently block unique (proteins/enzymes/molecules)to prevent production of a new virus.

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Question 9

Examine the diffusion susceptibility plate results shown in Figure 10.2.Propose an explanation for the appearance of the zone around the S/10 disk,and discuss the implications for therapeutic use of this antibiotic for the pathogen tested.

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Examine the diffusion susceptibility plate results...

Question 10

The ratio of a medication's dose that can be tolerated to its effective dose is the therapeutic (MIC/index/range)of the medication.

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Question 11

Competition between beneficial microbes and potential pathogens is called microbial (antagonisms/synergy/toxicity).

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Question 12

Drugs known as beta-lactams interfere with bacterial (DNA/folic acid/cell wall)synthesis.

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Question 13

A newly discovered prokaryote produces a compound with promising antimicrobial effects.Devise a set of tests to determine whether the antimicrobial is broad or narrow spectrum and bactericidal or bacteriostatic.

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Question 14

Explain the concept of selective toxicity.

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Question 15

Medications which block viral entry into cells include (adhesin/analog/attachment)antagonists.

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Quiz 10: Controlling Microbial Growth in the Body: Antimicrobial Drugs