Cofilin binds preferentially to ADP-containing actin filaments rather than to ATP-containing filaments. Consequently, this protein …
A) competes with profilin for actin binding.
B) binds to older actin filaments.
C) binds to the plus end of actin filaments.
D) stabilizes actin filaments.
E) All of the above.

Question

Quizplus · Accepted Answer

Cofilin induces twisting of older actin filaments and destabilizes them. ATP hydrolysis by incorporated actin is usually slower than filament assembly; therefore the new actin filaments in the cell are more resistant to depolymerization brought about by cofilin.

Cofilin Binds Preferentially to ADP-Containing Actin Filaments Rather Than to ATP-Containing