What type of depressive disorder is characterized by structural changes in the brain?

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Major depressive disorder can occur as a single isolated episode lasting weeks to months or intermittently throughout a person's life. Organic mood disorder is biologically based; structural changes in the brain associated with disease or brain trauma can cause depressed reactions. Bipolar disorder is characterized as multiple phases and varied presentations in each phase making diagnosis and treatment difficult and challenging. Frequent alterations of mood extremes are called cyclothymic disorder.

What Type of Depressive Disorder Is Characterized by Structural Changes