Which of the following heartworm medications should be used with caution in collies?

Question

Quizplus · Accepted Answer

Ivermectin should be used with caution in collies due to a genetic predisposition in some individuals of this breed that can lead to increased sensitivity and adverse reactions to the drug. This sensitivity is due to a mutation in the MDR1 gene (multi-drug resistance gene), which affects the drug's transport across the blood-brain barrier.

Which of the Following Heartworm Medications Should Be Used with Caution