The major reason for the tremendous death rate among Native Americans from disease during the sixteenth to seventeenth centuries was

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The lack of immunities among Native Americans was the major reason for the tremendous death rate from disease during the sixteenth to seventeenth centuries. Europeans brought diseases like smallpox and measles that Native Americans had never encountered before and were not immune to. This led to devastating epidemics that wiped out entire communities.

The Major Reason for the Tremendous Death Rate Among Native