The Nef Protein Helps HIV Evade the Adaptive Immune System

The Nef protein helps HIV evade the adaptive immune system by____.

A) destroying cytotoxic T cells
B) destroying class I MHC proteins present on the surface of infected cells
C) destroying class I MHC proteins in the cytoplasm
D) binding to class I MHC proteins at the cell surface, thereby blocking their availability to cytotoxic T cells
E) binding to class I MHC proteins  and preventing their transport to the cell surface