Which of these cancer drugs act(s) on the enzyme that pulls DNA apart?

Question

Quizplus · Accepted Answer

Topoisomerase inhibitors act on the enzyme that pulls DNA apart, preventing it from resealing and causing breakage in the DNA strand, ultimately leading to cell death. Alkylating agents attach an alkyl group to DNA, preventing normal DNA replication and causing cell death. Antimetabolites and nucleoside analogs disrupt DNA synthesis by incorporating themselves into the DNA strand or inhibiting purine/pyrimidine synthesis pathways. AZT is a nucleoside analog that inhibits reverse transcriptase, an enzyme used by retroviruses like HIV to replicate their genetic material.

Which of These Cancer Drugs Act(s) on the Enzyme That