The proteome,rather than genome,is most directly responsible for the structure,function,and appearance of organisms.

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While the genome provides the blueprint for an organism's proteins, it is the proteome - the entire set of proteins produced by an organism's genome - that actually carries out many of the functions of life, from catalyzing chemical reactions to providing structural support. The proteome can also be influenced by factors such as gene expression and post-transcriptional modifications, adding another layer of complexity to our understanding of how organisms work.

The Proteome,rather Than Genome,is Most Directly Responsible for the Structure,function,and