A 7-year-old girl is brought to the office for by her parent due to a concern of short stature. The patient's mother and father are 172.5 cm (5'8") and 183 cm (6') tall, respectively. On physical examination, the patient's height is 3 standard deviations below the mean for her age. Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus. Chromosomal analysis reveals a 45,XO karyotype. The patient is started on a medication to improve growth and normalize her height. Which of the following intracellular pathways is stimulated by the medication used in this patient?

Question

A 7-year-old girl is brought to the office for by her parent due to a concern of short stature.  The patient's mother and father are 172.5 cm (5'8") and 183 cm (6') tall, respectively.  On physical examination, the patient's height is 3 standard deviations below the mean for her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45,XO karyotype.  The patient is started on a medication to improve growth and normalize her height.  Which of the following intracellular pathways is stimulated by the medication used in this patient?

Quizplus · Accepted Answer

Eductional Objective: Growth hormone binds to cell surface receptors, leading to intracellular activation of the JAK-STAT pathway.  Cytokines (eg, interferon) and hematopoietic growth factors (eg, erythropoietin, G-CSF) also use this pathway

A 7-Year-Old Girl Is Brought to the Office for by Her