A 32-year-old woman, gravida 1 para 0, at 35 weeks gestation, presents to the emergency room owing to a 24-hour period of no fetal activity. The patient did not get any prenatal treatment. Fetal ultrasound confirms fetal death intrauterine. The fetus' autopsy revealed incomplete separation of the cerebral hemispheres with a single ventricle, as depicted in the figure below: Which of the following is most closely associated with this fetal condition?

Question

A 32-year-old woman, gravida 1 para 0, at 35 weeks gestation, presents to the emergency room owing to a 24-hour period of no fetal activity. The patient did not get any prenatal treatment. Fetal ultrasound confirms fetal death intrauterine. The fetus' autopsy revealed incomplete separation of the cerebral hemispheres with a single ventricle, as depicted in the figure below:  Which of the following is most closely associated with this fetal condition?

Quizplus · Accepted Answer

Eductional Objective: Holoprosencephaly occurs when the primitive forebrain (prosencephalon) fails to split into right and left hemispheres, resulting in a range of brain and midface abnormalities (eg, facial clefts, cyclopia). The most usually related cause is trisomy 13.

A 32-Year-Old Woman, Gravida 1 Para 0, at 35 Weeks