A 7-year-old boy is admitted to the hospital after his adoptive parents brought him to the emergency department due to fatigue and pallor. Laboratory evaluation reveals pancytopenia with an absolute neutrophil count consistent with severe neutropenia. Bone marrow examination reveals signs of aplastic anemia, and subsequent genetic testing reveals a congenital genomic defect in DNA repair leading to chromosomal instability. A bone marrow transplant is required for treatment. The patient's only living relatives are an identical twin brother and older sister who were both adopted by the same parents. He also has stored umbilical stem cells that were harvested after birth. Which of the following is the best bone marrow transplantation method for this patient?

Question

A 7-year-old boy is admitted to the hospital after his adoptive parents brought him to the emergency department due to fatigue and pallor.  Laboratory evaluation reveals pancytopenia with an absolute neutrophil count consistent with severe neutropenia.  Bone marrow examination reveals signs of aplastic anemia, and subsequent genetic testing reveals a congenital genomic defect in DNA repair leading to chromosomal instability.  A bone marrow transplant is required for treatment.  The patient's only living relatives are an identical twin brother and older sister who were both adopted by the same parents.  He also has stored umbilical stem cells that were harvested after birth.  Which of the following is the best bone marrow transplantation method for this patient?

Quizplus · Accepted Answer

Eductional Objective: Patients who require stem cell transplantation due to a congenital genomic disease typically receive matched unrelated donor cells because they will have matched human leukocyte antigen alleles but will not have the genomic mutation that caused the condition.

A 7-Year-Old Boy Is Admitted to the Hospital After His