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A Healthy 31-Year-Old Woman Arrives to the Office Because She

Question 58

Multiple Choice

A healthy 31-year-old woman arrives to the office because she and her husband want to have a second child. The patient's spouse is infertile, and her baby, conceived through donor insemination, was just diagnosed with glycogen storage disorder type II (Pompe disease) . This uncommon autosomal recessive condition affects 1 in 40,000 people in the general population. Genetic testing validates the patient's status as a disease carrier. A sperm donor with no personal or family history of Pompe disease is chosen; nonetheless, his carrier status is unclear. What is the likelihood that the patient will have an afflicted kid with the new sperm donor?


A) 1/4
B) 1/240
C) 1/400
D) 1/800
E) 1/40,000
F) 1/160,000

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