A 24-year-old man comes to the urgent care clinic due to painful swelling in his left groin. The patient noticed the swelling 2 days ago, and it has progressively become more tender and painful. He has no chronic medical conditions, but he recently sustained a puncture wound to the sole of his left foot. Physical examination shows an enlarged, tender, and nonfluctuant left inguinal lymph node with erythematous overlying skin. There is a small puncture wound on the sole of the left foot, which expresses pus upon mild pressure. Which of the following histologic findings is most likely responsible for this patient's groin mass?

Question

A 24-year-old man comes to the urgent care clinic due to painful swelling in his left groin.  The patient noticed the swelling 2 days ago, and it has progressively become more tender and painful.  He has no chronic medical conditions, but he recently sustained a puncture wound to the sole of his left foot.  Physical examination shows an enlarged, tender, and nonfluctuant left inguinal lymph node with erythematous overlying skin.  There is a small puncture wound on the sole of the left foot, which expresses pus upon mild pressure.  Which of the following histologic findings is most likely responsible for this patient's groin mass?

Quizplus · Accepted Answer

Eductional Objective: Germinal centers are the sites where activated B cells proliferate and undergo affinity maturation during generation of a humoral immune response.  The formation of multiple germinal centers is typically marked by lymphadenopathy, pain, and inflammation in the affected lymph node due to cellular recruitment and the release of inflammatory cytokines.

A 24-Year-Old Man Comes to the Urgent Care Clinic Due