A 32-year-old woman visits an allergy clinic because she has a recurring skin problem. Over the last few months, the patient has experienced many episodes of itchy, erythematous, vesicular eruptions on her hands. She works at a hair salon, where she is frequently exposed to hair color and other beauty products. There are no additional medical issues or drugs that the patient is taking. Several allergens detected in common cosmetic items are placed on nonocclusive tape strips applied to her upper back during patch testing. The exhibit depicts skin results that occurred after two days of treatment. Which of the following processes most likely occurred in this patient to enable the development of the observed skin reaction?

Question

A 32-year-old woman visits an allergy clinic because she has a recurring skin problem. Over the last few months, the patient has experienced many episodes of itchy, erythematous, vesicular eruptions on her hands. She works at a hair salon, where she is frequently exposed to hair color and other beauty products. There are no additional medical issues or drugs that the patient is taking. Several allergens detected in common cosmetic items are placed on nonocclusive tape strips applied to her upper back during patch testing. The exhibit depicts skin results that occurred after two days of treatment.  Which of the following processes most likely occurred in this patient to enable the development of the observed skin reaction?

Quizplus · Accepted Answer

Eductional Objective: Allergic contact dermatitis is a sort of hypersensitivity response that occurs later in life. Langerhans cells first migrate to regional lymph nodes and deliver haptens to naïve T cells, resulting in clonal proliferation. Sensitized T cells produce tissue damage when exposed to the hapten again 2-3 days later, manifesting as pruritic erythema, vesicles, and/or bullae.

A 32-Year-Old Woman Visits an Allergy Clinic Because She Has