A 44-year-old man comes to the physician because of progressive memory loss for the past 6 months. He reports that he often misplaces his possessions and has begun writing notes to remind himself of names and important appointments. He generally feels fatigued and unmotivated and has poor concentration at work. Neurologic examination shows mild ataxia and an inability to perform repetitive rotary forearm movements. Mental status examination shows a depressed mood and short-term memory deficits. Serum glucose, vitamin B12 (cyanocobalamin), and thyroid-stimulating hormone concentrations are within the reference range. Upper esophagogastroduodenoscopy shows streaky, white-grayish lesions. Viral proliferation in which of the following central nervous system cells is most likely involved in this patient's disease process?

Question

Quizplus · Accepted Answer

Eductional Objective: HIV-associated dementia has become rare since the advent of antiretroviral treatment but may still develop in patients with inadequately treated, late-stage HIV infection.  In the CNS, HIV preferentially infects and replicates in macrophages.

A 44-Year-Old Man Comes to the Physician Because of Progressive