A 3175-G (7-Lb) Female Newborn Is Delivered at 37 Weeks

A 3175-g (7-lb) female newborn is delivered at 37 weeks to a 26-year-old primigravid woman. Apgar scores are 8 and 9 at 1 and 5 minutes, respectively. The pregnancy had been uncomplicated. The mother had no prenatal care. She immigrated to the US from Brazil 2 years ago. Immunization records are not available. One day after delivery, the newborn's temperature is 37.5°C (99.5°F) , pulse is 182/min, respirations are 60/min, and blood pressure is 82/60 mm Hg. The lungs are clear to auscultation. Cardiac examination shows a continuous heart murmur. The abdomen is soft and nontender. There are several discolored areas on the skin that are nonblanchable upon pressure application. Slit lamp examination shows cloudy lenses in both eyes. The newborn does not pass her auditory screening tests. Which of the following maternal interventions would have most likely prevented this infant's condition?

A) Maternal administration of a killed vaccine during pregnancy
B) Maternal administration of a live attenuated vaccine before conception
C) Maternal perinatal antibiotic treatment
D) Maternal vitamin intake throughout pregnancy
E) Viral enzyme inhibitor drug intake during the third trimester