A 54-year-old man with HIV is part of a large clinical study. He was diagnosed with HIV-1 infection 5 years ago. Blood samples are obtained periodically to perform sequencing analysis of the viral genome. Current testing reveals a large number of isolates with mutation in the pol gene compared to the previous analyses. This finding is most closely associated with which of the following?

Question

A 54-year-old man with HIV is part of a large clinical study.  He was diagnosed with HIV-1 infection 5 years ago.  Blood samples are obtained periodically to perform sequencing analysis of the viral genome.  Current testing reveals a large number of isolates with mutation in the pol gene compared to the previous analyses.  This finding is most closely associated with which of the following?

Quizplus · Accepted Answer

Eductional Objective: HIV pol gene mutations are responsible for acquired resistance to reverse transcriptase inhibitors, protease inhibitors, and integrase strand transfer inhibitors.  Mutations of the env gene enable escape from host-neutralizing antibodies.

A 54-Year-Old Man with HIV Is Part of a Large